Osteopontin Enhances Endogenous Repair After Neonatal Hypoxic–Ischemic Brain Injury

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Osteopontin enhances endogenous repair after neonatal hypoxic-ischemic brain injury.

BACKGROUND AND PURPOSE Hypoxic-ischemic (HI) brain injury is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. To identify molecules important for cerebral damage and repair, we investigated the growth factor-related gene expression profile after neonatal cerebral HI. We identified osteopontin (OPN) as the most highly upregulated factor early after HI. We t...

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ژورنال

عنوان ژورنال: Stroke

سال: 2011

ISSN: 0039-2499,1524-4628

DOI: 10.1161/strokeaha.110.608315